Research on the Mechanisms of PM Effects: Supplement to Accomplishments of the Particulate Matter (PM) Centers (1999-2005)

This document summarizes additional mechanistic information obtained in the first 6 years of the PM Centers’ research since their establishment in 1999. Research performed as part of the EPAfunded Particle Centers has increased the understanding of the mechanisms of PM health effects. Progress has been made in understanding the dosimetry and distribution of particles throughout the body, pulmonary inflammation and vascular effects, asthma and allergen responses, cardiac effects, vascular and systemic inflammatory effects, and possible impact on the central nervous system. These findings have increased our understanding of the mechanisms of injury at the organ, tissue, cellular, and subcellular levels, and have begun to shed light on systemic interactions in the whole organism that contribute to adverse health outcomes.